Inspired on that treat http://scn.sap.com/thread/3354028 i just update a blog post for share own diagnostics in send to sap errors
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Check to follow if you found erorr "message can't be sent to SAP"
- the user that has create the message/operation is not maintained on AISUSER table
- the sap customer number that send the message is not really a customer from your VAR, check with sap contracts department
- check RFC SAPOSS connection
- the user is not update as BUP003 con BP
- the maintenance agreement of the customer is not up-to-date with SAP
- chec autorizations on sap marketplace
- the system for that message has been creates is not on marketplace or product is not installation relevant like AFARIA or SyBase
Regards,
Luis